海马齿状回颗粒细胞弥散化（GCD）是颞叶内侧癫痫（MTLE）的一种常见病理表现并与疾病发生密切相关，但其产生机制尚不完全清楚。相关研究表明Reelin蛋白水平下降和Reelin基因启动子区域DNA甲基化水平增高与GCD相关。我们前期研究发现DNA甲基化/组蛋白乙酰化调控HCN基因表达在MTLE形成中发挥重要作用，预实验发现大鼠MTLE模型中Reelin表达水平下降，文献报道Reelin-Dab1-Rap1信号通路与神经母细胞迁移相关。我们提出Reelin-Dab1-Rap1信号通路参与GCD形成和MTLE发生并受到DNA甲基化/组蛋白乙酰化调控这一科学假说。基于此科学假说，我们分析DNA甲基化/组蛋白乙酰化调控Reelin-Dab1-Rap1信号通路在MTLE发生中的作用，探究干预DNA甲基化/组蛋白乙酰化调控对Reelin-Dab1-Rap1信号通路的影响及抑制MTLE的治疗前景。

Dentate gyrus granule cell dispersion (GCD) is a common pathology of the mesial temporal lobe epilepsy and closely associated with the disease, but its mechanism is unclear. Recent studies show that the decrease of Reelin protein level and the increase of DNA methylation level in Reelin promoter are related to GCD. We previously found that DNA methylation / histone acetylation in the regulation of gene expression of HCN play an important role in MTLE. In our preliminary study, the decreased level of reelin gene expression has been observed in rat MTLE model. Some research reported Reelin-Dab1-Rap1 signaling pathway is associated with neuroblast migration. We propose this scientific hypothesis that Reelin-Dab1-Rap1 signaling pathway involved in the formation of GCD and MTLE, which regulated by DNA methylation / histone acetylation. Based on this hypothesis, we analyzed the role of DNA methylation / histone acetylation mediated Reelin-Dab1-Rap1 signal pathway in MTLE formation. Intervention in DNA methylation/histone acetylation regulation of Reelin-Dab1-Rap1 signaling pathways and restrain the influence of MTLE prospect of treatment.