宁夏回汉变应性鼻炎与微量元素和MRPL4 ，BCAP基因多态性研究

变应性鼻炎（AR）患病率不断上升，发病机制尚不清楚，其中环境与基因相互作用成为研究焦点。微量元素参与人体免疫功能多个环节的调节，与环境的丰缺密切相关，在AR发病机制中所起作用国内外相关研究甚少,结论不一。尚未见到回汉种族间研究的报道，唯一AR的GWAS发现了2个候选基因MRPL4和BCAP基因。研究者前期工作示宁夏AR回汉患病率存在显著性差异，在学龄前儿童差异更为显著；AR患者的微量元素含量在回汉族间存在显著性差异。本课题随机抽取宁夏常住人口4800例，进行AR流行病学调查, 对调查中的AR患者按回汉族分组，设正常对照组,用MP-2溶出分析仪对血清中的微量元素进行检测；同时用PCR方法MRPL4和 BCAP基因多态性检测。本研究填补宁夏AR的流行病资料空白；得出宁夏回汉族AR微量元素及易感基因的表达特点；分析其相关性；认识环境如何改变AR基因易感性，为AR病因学研究及防治提供新的思路。

Allergic rhinitis (AR)have increased in prevalence in recent decades which pathogenesy is not clearly. Recent reports have suggested a key role of complex interplay between genetic and environmental factors. Trace elements play an important role in the immune system which is closely related to the abundance and deficiency of environment. The only GWAS study for AR finds the two candidate gene: MRPL4 and BCAP gene。In previous work，It has been shown trace elements of AR has significant difference to hui and han in Ningxia region, especially in preschool children. Method: epidemiological survey of AR in 4800 people in Ningxia region ; trace elements was detect with MP-2 Stripping analyzer;; PCR（polymerase chain reaction） were used to test MRPL4 and BCAP gene.. In this study, it will get the latest data of epidemiological survey of AR in Ningxia region, and the relation between the trace elements and immune response, susceptibility genes;from this point ,it may be explain the characteristics of complex interactions between genetic and environmental factors and provide a theoretical basis for the pathogenesis of AR.