腹腔复苏是一种新的复苏方式，即将临床腹膜透析液直接注入到腹腔中，作为休克传统液体复苏的一种补充治疗手段，以保护内皮的正常反应，逆转内脏器官的低灌流。由于现用乳酸钠腹膜透析液对宿主防御细胞有明显毒性作用，且有加剧致死/难治性休克乳酸性酸中毒可能，因此有必要进一步寻求更加安全有效的腹腔复苏液。鉴于丙酮酸盐能直接纠正乳酸性酸中毒、消除或减轻葡萄糖与乳酸的细胞毒作用、具有体外保护血管内皮细胞和红细胞/携氧的功能，几乎没有乳酸盐的副作用，我们推测丙酮酸盐替代乳酸盐腹腔复苏可能具有更好的治疗价值和安全性，从而更好发挥腹腔复苏的治疗优势。本研究以丙酮酸盐代替乳酸盐腹膜透析液对失血性休克家兔进行常规腹腔复苏治疗，通过观察丙酮酸盐透析液腹腔复苏对休克家兔血流动力学、免疫反应、肠道粘膜屏障、酸碱平衡以及内脏器官血流等的影响，探讨其在休克救治中的价值和安全性，为其可能的临床应用提供实验基础和科学依据。

Direct peritoneal resuscitation(DPR) is a new resuscitation method of shock. As a complementary therapy, the DPR is to directly inject clinical peritoneal dialysis solution into the peritoneal cavity to protect the normal endothelial reactivity, reversing low perfusion of the internal organs. However, since the sodium lactate peritoneal dialysis solution currently used by DPR has significant toxic effects on the defense cells and may aggravate the lactic acidosis in fatal / refractory shock, a more secure resuscitation solution is needed to ensure the clinical effects of DPR. Pyruvate can directly correct the lactic acidosis, eliminate or reduce the cytotoxic effects of glucose and lactic acid, protect the vascular endothelial cells and red blood cells / oxygen-carrying function, and almost has no side effects of the lactate. Thus, we infer that DPR with pyruvate peritoneal dialysis solution instead of lactate peritoneal dialysis solution may have higher therapeutic value and security. Therefore, This study is to through the pyruvate peritoneal dialysis solution instead of lactate peritoneal dialysis solution on the DPR of hemorrhagic shock in rabbits, explore its value and safety in the therapy of shock by observing the indicates of hemodynamics, mmune response, intestinal mucosal barrier, pH, and visceral organ blood flow, etc. Our experimental results may provide further theoretical support and scientific basis for the probable clinical application of the pyruvate dialysis solution peritoneal resuscitation on the shock and the internal organs protection treatment.