类风湿关节炎（RA）是公认的难治性疾病，本团队前期的研究表明蒙药忠伦阿汤（三子汤加苦参、肋柱花）能有效抑制胶原诱导性关节炎（CIA）鼠模的关节炎性指数，炎性细胞因子、基质金属蛋白酶等，在此基础上，挖掘梳理相关古籍文献，与其关系密切的三子汤、森登-4（三子汤加文冠木）对 CIA鼠模是否有效？基础方三子汤 “分离恶血和正血”的神奇功效，却未见深入报道。本研究拟建立CIA关节炎大鼠模型，以RA病理核心机制“新生血管形成”为切入点，采用影像学、ELISA，免疫组化、Western Blot、血清药理、流式细胞等，以三子散、森登-4、忠伦汤-5系列方进行干预，设雷公藤为阳性对照，从血液、组织、细胞培养等层次，观察不同方药组对CIA鼠模关节滑膜病理、微血管密度、血流及凝血变化，致炎因子、干扰素及与血管内皮损伤异常增殖等指标的影响，并对系列方进行初步拆方比较，探讨蒙医方剂配伍理论的合理与科学性，并为优化

Rheumatoid arthritis (RA) is recognized as intractable diseases. Previous studies of our team show that the articular inflammatory index, inflammatory cytokines and MMP of collagen-induced arthtitis rat model can be restrained effectively by Mongolian medicine Zhongluna decoction ( Sanzi decoction combined with Kushen and Leizhuhua ).On the basis of those results, exploring the related literature, it is wondered that if Sanzi decoction and Sendeng-4（Sanzi decoction combined with Wenguanmu )which related to Zhongluna decoction work for CIA rat model? Not yet get any deeply reports about the magical effect of separating healthy blood and ill blood by the basic prescription Sanzi decoction have not been reported yet. .This study employs the core pathological mechanism of RA, "neovascularization", as breakthrough point. Aims at exploring the rationality and scientific nature of Mongolian medical prescription composition theory, providing experimental bases for optimized formula, increasing scientific connotation and creating a new approach for RA clinical treatment. Using series prescriptions of Sanzi decoction, Sendeng-4 and Zhonglun-5 as treatment drug, and tripterygium as control drug, to observe the effect of pathophysiologic indicators, such as different prescriptions affecting on CIA rat about synovial joint pathology, microvessel density (MVD), changes of blood flow and blood clotting, proinflammatory cytokines, interferons and abnormal proliferation of endothelial damage etc, by methods of imageology, ELISA, Immunohistochemistry(IHC), Western Blot, Serum pharmacology and flow cytometry etc.