三氟甲磺酸金属盐促进的生物质基含氧化合物选择性加氢脱氧反应

以可再生资源为原料的催化转化是现代化工行业可持续发展的必经之路。尽管有机合成方法学已经发展了许多官能团引入的策略，但对于过度含氧官能团化的生物质原料，一个新的挑战是发展选择性去除或保留特定含氧官能团的合成方法。本项目根据生物质基平台化合物含有大量不同含氧基团这一结构特性，在生物质催化转化制取化学品的研究方向上，针对“如何实现对生物质基含氧化合物进行选择性加氢脱氧”这一关键科学问题，拟通过采用三氟甲磺酸金属盐+加氢催化剂的复合催化体系，运用实验研究和理论计算相结合的手段，针对生物质基糖类、酚类以及纤维素基平台化合物的缩合衍生物，系统地对生物质基含氧化合物加氢脱氧反应的过程、催化剂的构效关系和催化作用机制进行研究。实现生物质基含氧化合物在不同反应途径上、不同反应基团上以及同种基团不同反应区域上的高效、高选择性的加氢脱氧反应，为生物质催化转化制取高附加值生物基化学品提供新的方法。

The catalytic transformation of renewable resources as raw materials is the only way for the sustainable development of modern chemical industry. Although organic synthesis methodology has developed strategies for the introduction of many functional groups, a new challenge for over-oxygenated functionalized biomass feedstocks is the development of synthetic methods for selective removal or retention of specific oxygen-containing functional groups. Based on the structural characteristics of biomass-based platform compounds bearing a large number of different oxygen-containing groups, this project puts forward “How to Achieve Selective Hydrodeoxygenation of Biomass-derived Oxygenated Compounds” as the key scientific issue in the research direction of biomass catalytic conversion. Based on the composite catalytic system of metal triflate + hydrogenation catalyst, the derivatives of biomass-based saccharides, phenols and cellulose-based platform compounds will be researched in combination with experimental and theoretical calculations. The process of hydrodeoxygenation of biomass-based oxygenated compounds, the structure-activity relationship of catalyst and the mechanism of catalysis will be systematically studied, with the aim to achieve efficient and highly selective hydrodeoxygenation of biomass-based oxygenated compounds on different reaction pathways, different reaction groups and different reaction zones of the same groups, and provides a new method for biomass catalytic conversion.