肥胖对儿童烧烫伤预后的影响及MCP-1在其中的角色研究

烧烫伤对健康危害严重，轻者皮肤坏死留下疤痕，重者功能障碍和残疾，甚至导致死亡。儿童烧烫伤不仅给孩子自身带来无尽的痛苦，还会危害家庭幸福，增加社会的疾病负担。而儿童肥胖现已成为一种全球公共卫生问题，既往研究表明，肥胖可致细胞因子和代谢改变，引起免疫能力下降，使机体更加易于感染，这可能对烧烫伤的预后造成不利影响。单核细胞趋化蛋白1(MCP-1)作为炎症因子的典型代表，在烧烫伤儿童康复过程中的确切效应以及是否会受到肥胖因素的影响及程度大小尚不清楚。本研究通过队列研究方法，收集肥胖烧烫伤儿童和对照的一般人口学资料、肥胖情况、烧烫伤程度与预后情况等资料，探索肥胖对儿童烧烫伤预后的影响程度；并通过析因设计的动物模型探讨肥胖对烧烫伤大鼠代谢与MCP-1的影响及时间效应，阐明肥胖对儿童烧烫伤预后的影响及MCP-1在其中的角色。研究结果对阐明肥胖对儿童烧烫伤的影响，指导治疗及预测预后均有重要参考价值。

Burn is one type of serious injuries, and it can lead to a series of problems such as skin necrosis, scars, dysfunction and disability, or even to death. Childhood burns not only bring pains to children themselves for a long time, but also harm their families, increase disease burden to the whole society. Up to now, childhood obesity has become a public health problem world widely. Previous studies showed that obesity could cause cytokines and metabolism changes, decrease immune function, and make the body more susceptible to infection, which may adversely affect the prognosis of burns. As a typical and important inflammatory cytokine, the exact effect of monocyte chemoattractant protein-1 (MCP-1), and whether it will be affected by obesity in the rehabilitation process in burned children are still unclear. In this study, we aim to use a cohort study to collect the children's general demographic data, obesity degree, burns-related information including the percentage of total burn surface area (TBSA) and the prognosis of burns, to explore the role and degree of obesity on the prognosis of childhood burns. We also prepare to use animal models by factorial design to explore and clarify the role and time effect between obesity and metabolism and MCP-1 on the prognosis in young burned rats. Our research can clarify the impact of obesity and MCP-1 on children's burns, and even to offer a pathway of giving a guide on the treatments, or predicting the prognosis in childhood burns especially for obese burned children.