生物启发型BTZnO纳米载药系统的构建及其靶向治疗卵巢癌的作用与机制研究

肿瘤治疗迫切需要具有高效、低毒、特异、稳定、缓释等性能的靶向药物，纳米药物递送系统是极具前景的实现途径之一。但生物相容性是困扰大多数纳米载体的问题，为此，本课题组基于生物启发合成的新策略，获得了具有天然高生物相容性的氧化锌纳米颗粒（BTZnO），并证实对几种深部肿瘤及易转移肿瘤具有靶向性。令人意外的是，BTZnO对卵巢癌的靶向性更强，因此被我们首先应用于卵巢癌的靶向治疗研究；进一步实验发现BTZnO表面蛋白冠成分与其靶向卵巢癌的功能存在联系。为发展疗效确切且具有应用潜力的卵巢癌靶向治疗策略，本研究拟探讨BTZnO靶向卵巢癌的作用、分析BTZnO表面蛋白冠的成分及其作用途径、评估BTZnO负载与控释卵巢癌治疗药物的能力、论证载药BTZnO靶向卵巢癌组织精准治疗的功能。如获成功，有望为卵巢癌靶向治疗提供一种新型的纳米药物载体，也为其他肿瘤的靶向治疗研究提供新线索，具有较好的创新性和转化前景。

Targeted drug with high efficiency, low toxicity, specificity, stability, controlled release and other performance is urgently needed for oncotherapy, therefore, nano drug delivery system emerges as one promising way. However, biocompatibility becomes a key issue brothering most nano drug delivery, for this purpose, our group obtained ZnO nanoparticles (BTZnO) with high natural biocompatibility based on the new strategy of bio-inspired synthesis, and verified its targeted therapy functions to several tumors. Surprisingly, BTZnO had greater targeting on ovarian cancer, so it was applied to research targeted therapy of ovarian cancer, and further to explore relation between BTZnO surface protein corona components and targeting ovarian cancer. In order to develop targeted therapy strategy of ovarian cancer with exact effect and application potential, the research attempted to explore function of BTZnO targeted therapy on ovarian cancer, analyse components and function way of BTZnO surface protein corona, assess BTZnO ability of loading and controlled release of ovarian cancer medicine, and demonstrate accurate drug release of medicine-loading BTZnO targeted ovarian cancer tissue. The above research was successful and helpful to provide a brand new nano drug delivery for targeted therapy of ovarian cancer, and new clue for targeted therapy research of other tumors, besides, it had better innovation and transformation prospects.