HRV 感染是导致全球范围内 5 岁以下婴幼儿急性脱水腹泻的主要原因。前期研究发现：七味白术散能通过调节IECs相关炎症因子的表达，影响上皮细胞连接分子表达，增强iELs细胞亚群γδ+T杀伤能力，保护HRV 感染肠道粘膜。提示:七味白术散有可能是增强了 IECs和IELs抗HRV感染中的相互调节作用。因此,进一步采用细胞培养氨基酸稳定同位素标记、数据生物信息学处理、qRT-PCR试验、免疫荧光分析、胰酶渗透实验、Western Blot以及Transwell 实验等，观察分析HRV感染上皮细胞快速脱落以及七味白术散保护肠上皮细胞的机制；IECs炎症小体与相关抗病毒物质表达；lELs及亚群活化和杀伤靶细胞功能; IECS和IELS在抗HRV感染过程中相互影响的作用，为肠道病原生物感染性疾病的防治疗提供新策略和思路。

Rotavirus (HRV) is the primary cause of acute dehydrating diarrhea worldwide in infants and young children under 5 years of age. Previous studies found that: Qiweibaizhu powder can regulate the expression of inflammatory factors of the IECs， affect the expression of molecules connected IECs， enhanced IELs γδ + T cell subsets killing capacity，Making the intestinal mucosa was HRV infection, get protected. Tips: Qiweibaizhu Powder possible by enhancing the mutual regulation of IECs and IELs, and anti-HRV infection. Thus, Further use of stable isotope labeled amino acids in cell culture, Bioinformatics data processing, qRT-PCR test，Immunofluorescence analysis，Trypsin permeation experiments, Western Blot and Transwell experiments, etc., Observation and analysis, HRV infected IECs is fast shedding and Qiweibaizhu powder on IECs protection mechanisms; IECs inflammation associated bodies and expression of antiviral substances; function lELs its subsets activation and kill target cells; IECs and IELs their interaction effects in the course of anti-HRV infection. For the prevention and treatment of intestinal infectious disease pathogens, provide new strategies and ideas.