葡萄膜炎是一类严重威胁青壮年视力的免疫性眼病，病因复杂，治疗不当可致失明。该病的病理基础为CD4+T淋巴细胞及相关细胞因子构成的免疫网络发生紊乱，其中最关键的由CD4+T淋巴细胞两种亚型-Th1/Th17淋巴细胞介导所产生，我们的预试验结果提示穴位埋线法对慢性葡萄膜炎患者T淋巴细胞亚群具有双向调节作用。提出其可能干预Th1/Th17通路的假说。通过建立自身免疫性葡萄膜炎动物模型在穴位埋线方法干预后，采用QRT-PCR、酶联免疫、流式细胞检测等手段，从分子、细胞、组织病理及眼形态学水平等多方面探讨该法对Th1/Th17淋巴细胞浓度的影响及相关细胞因子表达, 明确其在葡萄膜炎免疫微环境的调节作用。阐述穴位埋线干预EAU大鼠模型的有效机制，揭示穴位埋线法与改变葡萄膜炎病程中Th1/Th17免疫微环境的相关性，研究将进一步丰富EAU的研究思路, 为葡萄膜炎的中医外治疗法提供科学依据和新的研究思路。

Uveitis is a serious threat to young adults vision autoimmune eye disease,causes complex,improper treatment can cause blindness.Disease pathological basis of CD4+T cells of the immune network,and related cytokines disorder,the most critical CD4+T lymphocytes two subtypes-Th1/Th17 lymphocyte mediated arising from our pre-The experimental results suggest that the catgut implantation method has bidirectional regulation of T lymphocyte subsets of patients with chronic uveitis.Proposed the possible intervention Th1/Th17 pathway hypothesis.Multifaceted explore means through the establishment of autoimmune uveitis animal models after the catgut embedding methods intervention,using QRT-PCR,ELISA,flow cytometry,molecular,cellular,and pathologic tissue and eye morphological levelthe method Th1/Th17 lymphocyte concentration and cytokine expression,clear its regulatory role in uveitis immune microenvironment.Elaborate catgut embedding intervention EAU rat model of effective mechanism reveals the catgut embedding method to change the course of uveitis Th1/Th17 the immune microenvironment correlation,the research will further enrich the EAU research ideas,as uveitis TCM external treatment to provide a scientific basis and new research ideas.