前列腺癌是男性最常见的恶性肿瘤之一，它的侵袭性关系到肿瘤治疗方案的选择及预后的判断，因此前列腺癌侵袭性的评估越来越受临床重视。磁共振氨基质子转移成像（APT）是能够特异性检测细胞内游离蛋白质与多肽的新型分子磁共振成像序列。前期实验中，本课题组已证明APT成像在前列腺癌早期诊断方面存在一定价值，在此基础上，我们提出了“APT序列能够通过探测前列腺肿瘤细胞内游离蛋白质与多肽的浓度预测肿瘤的侵袭性”的假设，并通过医学影像学与组织病理学、分子生物学相结合的手段，拟回答以下科学问题：①APT序列能否用于前列腺癌侵袭性的评估？②APT序列在前列腺癌侵袭性评估方面是否优于其他磁共振成像技术？③APT序列评估前列腺癌侵袭性的生物学基础是什么？本研究旨在发展一种能够无创、精准的评价前列腺癌侵袭性的分子影像学成像手段，为临床诊疗提供更精确的依据。

Prostate cancer is the most common male malignancy, the invasive evaluation get more and more clinical attention because it's related to cancer treatment options and prognosis assessment. Amino proton transfer magnetic resonance imaging is a specific MR sequence which can detect intracellular proteins and peptides. In preliminary study, we have proved that APT MRI is feasible in prostate cancer early diagnosis. Based on this result, we hypothesize that APT sequence can predict invasion degree of prostate cancer through detection free protein and peptide within prostate tumor cell. Our study intends to answer the following scientific questions: ① Is APT MRI feasible for prostate cancer invasion assessment? ② Does APT MRI perform better than other MRI sequences in assessment of prostate cancer invasiveness? ③ What's the biological basis of APT series? This study aims to develop a non-invasive and accurate tool of prostate cancer invasive assessment, which can provide more information for clinical diagnosis and treatment.