超分子手性光化学是利用超分子主客体作用来控制和提高不对称光化学反应选择性的便捷且有前景的新策略。目前用于调控手性光化学反应的超分子主体存在种类少、手性特征和识别位点固定、立体选择性差等缺点。本项目拟设计合成多种新型手性Octa Acid(OA)衍生物，并以其作为超分子主体调控手性光化学反应的立体选择性。合成对映异构的手性OA衍生物，研究其与不同光反应底物之间的主客体作用以及调控不同类型的手性光化学反应；将OA与环糊精共价连接合成杂化主体，利用双重主体的协同作用提高手性光反应的特异性和选择性；通过优化主体结构以及外部环境条件实现高立体选择性手性催化；探索手性OA主体的结构与手性光催化性能之间的构效关系并提出手性光催化机理。通过本项目的实施，有望实现对手性光化学反应的特异性和高立体选择性的调控，建立超分子手性光催化的新策略。

Supramolecular chiral photochemistry is a convenient and promising new strategy to control and improve the selectivity of asymmetric photochemical reactions by supramolecular host-guest interactions. Supramolecular hosts exploited for chiral photochemical reactions so far are scare and have disadvantages of fixed characteristics and chiral recognition sites, and low stereoselectivity. This project intends to design and synthesize a variety of novel chiral octa acid (OA) derivatives as supramolecular hosts to manipulate the stereoselectivity of chiral photochemical reactions. We plan to design and prepare enantiomeric chiral OA derivatives. Then we will study the host-guest interaction of chiral OA derivatives with various photoreactive substrates, and further perform the chiral photochemical reactions. We synthesize the hybrid hosts by covalently linking OA with cyclodextrin, and the specificity and selectivity of the chiral photoreaction will be improved by the synergistic effect of the dual hosts. Highly stereoselective chiral photochemical reactions will be achieved by further optimizing the host structure and external environmental conditions. We will investigate the relationship between the OA structure and photo-chirogenic performance, and reveal the mechanism operative in this supramolecular photochirogenesis. By this research, it is expected to achieve high specificity and stereoselectivity in chiral photochemical reactions, and thus to establish a new strategy for supramolecular photochirogenesis.