探索共抑制复合体组分Tbl1xr1在肝脏再生中的作用

哺乳动物的肝脏在受到损伤时可以在较短时间内再生，恢复其功能、大小和结构，但驱动肝脏增殖的机制和主要细胞来源尚未完全明确。最近，基于谱系追踪的研究与我们利用新一代高精度空间转录组测序的研究均表明，肝脏中间区带的肝实质细胞是驱动肝脏再生和稳态维持的主要细胞来源，并且我们进一步找到了在再生过程中，中间区带肝实质细胞中高富集的调控因子，包括共抑制复合体组分Tbl1xr1。因此，本项目我们提出针对共抑制复合体组分Tbl1xr1在肝脏再生和稳态维持中的作用，进行体外、体内的功能探索，期望找到促进肝脏再生的新机制。

The mammalian liver has the capacity to restore the structure, size, and function after acute or chronic injury in a short period of time. But the mechanism and cell sources driving the liver regeneration were largely unknown. Recently, lineage tracing based studies and our high-resolution spatial transcriptome study both reveal midzonal hepatocytes are the source for liver regeneration. And we also identified a series of transcription factors that highly enriched in midzonal hepaocytes, including co-repressor subunit Tbl1xr1. Thus, we proposed to study the function of Tbl1xr1 in liver homeostasis and regeneration both in vivo and in vitro. We expect to find new mechanism driving liver regeneration.