基于多模态影像组学的肝段结构、功能和病理特征研究

肝细胞癌是严重影响国人健康的重大疾病，肝切除术是肝细胞癌最主要局部根治手段。在肝脏外科领域，实现目标病灶彻底清除与肝脏功能充分保护之间的最佳平衡，是长期以来探索解决的关键科学问题。随着精准肝胆外科理念和范式的建立与应用，当代肝胆外科进入“肝段时代”，以肝段为本的肝切除术基于肝段生理病理特征，追求在彻底去除病变同时，最大限度保护肝脏储备功能。然而，肝段解剖构象、生理功能和病理特征的复杂性决定肝段手术极具挑战性和风险性。本项目基于精准外科理念，组建医理工融合、产学研一体化的科技创新联盟，应用以影像组学、数字外科和人工智能等前沿技术为代表的多种现代科技手段，首次在肝段水平量化解析肝脏脉管解剖、生理功能和病理学特征，从病情评估、手术设计和手术导航多个层面，为解决制约肝段外科发展的定构、定量和定位三个瓶颈问题提供系统解决方案，为肝段切除为本的肝细胞癌等疾病的精准手术治疗提供科学理论基础和核心技术支撑

Hepatocellular carcinoma (HCC) seriously affects the health of Chinese, for which hepatectomy is the most important local radical treatment. It has been a key issue to achieve the best balance between the complete removal of target lesions and adequate protection of hepatic functional reserve in liver surgery for a long time. Nowadays, hepatobiliary surgery has entered the era of "liver segment" with the establishment and application of the concept and canonical form of precise hepatobiliary surgery. Segment-based hepatectomy, which is based on the physiological and pathological characteristics of the liver segment , seeks to completely remove the lesions while maximizing the protection of hepatic functional reserve. Nevertheless, the complexity of anatomical structure, physiological function and pathological characteristics of hepatic segments determines that segmental hepatectomy is extremely challenging and risky. Based on the concept of precise surgery, this project establishes a science and technology innovation alliance which combines medicine, science and engineering, as well as integrates scientific research, education and production. This project quantitatively analyzes the anatomical, physiological and pathological characteristics of hepatic vessels with the application of various modern scientific and technological means, such as radiomics, digital surgery, and artificial intelligence. Thus, this project provides a systematic solution to the bottlenecks (structuring, quantitating and locating) that restricts the development of segmental surgery from the aspects of illness condition assessment , surgical design and navigation, as well as offers scientific theoretical basis and core technical support for segmentectomy-based precise surgical treatment of HCC and other diseases .