基于前期研究基础，本项目围绕针灸临床疗效预测这一尚不明确规律和机制的针灸临床重要问题，整合神经影像组学、基因多态性、认知行为学和针灸学多学科技术方法，以针灸临床优势病种偏头痛为研究对象，以大脑奖赏回路相关脑区为研究重点，融合COMT rs4680基因多态性分析和认知行为学测评，围绕“COMT rs4680基因调控的多巴胺介导的奖赏回路是针刺治疗偏头痛疗效预测的重要神经回路”这一研究假说，第一阶段：构建针刺治疗偏头痛疗效预测模型；第二阶段：对比针刺与偏头痛预防一线用药氟桂利嗪、对比针刺治疗不同类型疼痛（紧张型头痛、慢性膝痛）以验证此模型的特异性；第三阶段：对已构建的针刺治疗偏头痛疗效预测模型进行前期已采集数据再验证以测试此模型的稳定性，以期深入探讨针刺治疗偏头痛疗效预测的部分规律和机制，为针灸治疗偏头痛的疗效预测的临床运用提供可视化依据，也将为针刺治疗慢性疼痛疗效预测研究提供新的思路和借鉴。

This research, based on the important acupuncture clinical problem of benefits prediction for acupuncture treatment which has unclear mechanism, uses multidisciplinary techniques including neural radiomics, genetic polymorphism, cognitive-behavior and acupuncture. We used migraine as the subject which acupuncture has advantage efficacy, aiming the mechanism of brain reward circuit and combining Catechol‐O‐methyltransferase (COMT) Val158Met (rs4680) polymorphism and cognitive-behavior therapy, around the hypothesis that "dopamine-mediated reward circuit regulated by COMT rs4680 gene is an important neural circuit for benefits prediction of acupuncture treatment for migraine". The first stage: establishing the prediction model of the efficacy of acupuncture treatment for migraine. The second stage: through comparison of acupuncture and first-line medication for migraine prevention flunarizine, and comparison of acupuncture treatment for different types of pain (tension-type headache, chronic knee pain) to verify the specificity of the model. The third stage: the former fMRI data of acupuncture treatment for migraine was used to test the stability of the model, to probe into the regularity and mechanism of the benefits prediction of acupuncture treatment for migraine. It will provide a scientific visual basis for the clinical application of benefits prediction of acupuncture treatment for migraine, and will also provide a new thought and reference for benefits prediction of acupuncture treatment for chronic pain.