国人脊神经系统的磁共振神经显像与测量分析研究

脊柱外科临床操作中脊神经解剖学知识不足是脊神经医源性损伤的重要影响因素。以往关于国人脊柱神经结构研究多以尸体标本直接进行测量分析，我们在前期项目（81071438）脊柱解剖学系统分析的基础上发现，以尸体标本进行脊神经解剖学研究与测量存在诸多不足。我们的研究表明磁共振神经成像技术（MRN）有望成为脊神经形态成像与解剖测量的理想工具。因此，本研究拟选取30 具新鲜尸体标本分别采用MRN 成像与传统解剖操作对脊神经进行测量比较，从而验证MRN 技术对脊神经解剖学研究的准确性；进而根据身高、性别等因素选取180名汉族健康成人志愿者进行MRN 脊神经显像，对脊神经固有解剖参数和其毗邻结构的解剖学参数进行测量，综合分析脊神经解剖变异状况。从解剖学视角对常见医源性脊神经损伤的原因进行系统分析，为规范性的脊柱临床手术方案的选择制定和术中操作规范提供科学依据，它将大幅降低脊神经医源性损伤的发生。

Lack of spinal anatomy knowledge is an important factor affecting the spinal nerve iatrogenic injury in clinical operations of spine surgery. Previous studies on the spinal nerves mostly adopted cadavers and directly measured and analyzed. We found that there were many deficiencies in spinal anatomical research and measurement by cadavers, based on our previous projects (81071438) spine anatomy studies. Our research group's preliminary study results have demonstrated that Magnetic resonance neurography(MRN) might be an ideal choice for imaging and measurement of spinal nerves. The study intends to adopt the MRN imaging and traditional anatomy operation to measure the spinal nerve structure parameters in 30 fresh cadavers, and to demonstrate the feasibility and accuracy of MRN technology by comparing the measurement results. And according to height, gender and other factors, further select 180 Han people healthy adult volunteers and have the MRN spinal nerve imaging. Measure the inherent anatomical parameters, the parameters of adjacent structures of the spinal nerves by the MRN technology, and further study the anatomical variations of spinal nerves. From an anatomical perspective, to analyze systematically the common causes of iatrogenic spinal nerve damage, to provide a scientific basis for the selection of spinal surgical program and intraoperative management in clinical practices, which will significantly reduce the incidence of iatrogenic injury of the spinal nerves.