帕金森病是中老年人常见的神经退行性疾病，其致残率高、误诊率高，严重地影响着中老年人的健康。帕金森病的早期临床表现不典型，诊断和病情评估主要依靠医生的临床诊断，尚缺乏客观的生物学指标。探索有效的生物学标志物有望提高帕金森病早期诊断的准确率,也可用于帕金森病防治和预后评估。本项目采用遗传学、分子生物学和功能影像学方法研究多巴胺转运体（dopamine transporter, DAT）基因 3’非翻译区变异在帕金森病发病中的作用，以便发现新的生物标记物。用DAT特异示踪剂11C-β-CFT进行PET-CT显像，分析阳性位点与纹状体11C-β-CFT摄取之间的相关性，探讨多巴胺转运体基因3’非翻译区变异在帕金森病早期诊断中的作用及其机制，该项研究将为深入理解帕金森病的遗传易感性，以及为帕金森病患者的风险预测和个体化防治提供科学依据。

Parkinson's disease is a common neurodegenerative disease in the elderly, its high morbidity and misdiagnosed rate seriously affects the health of the elderly. Early symptoms of Parkinson's disease are not typical and lack of objective biological indicators, the diagnosis and severity assessment relies mainly on clinical diagnosis of doctors. Effective biomarkers can improve the accuracy of early diagnosis of Parkinson's disease and contribute to prevent and assess the prognosis. In our project, we using genetics, molecular biology and functional imaging techniques investigate the association between 3’ untranslated region variants of dopamine transporter and Parkinson's disease；PET-CT imaging was performed with DAT-specific tracer 11C-β-CFT in order to analyze the correlation between positive sites and 11C-β-CFT-DAT uptake in striatal. Our project investigates the role of 3’ untranslated region variation of dopamine transporter gene in early diagnosis of Parkinson's disease and its mechanisms. The study will provide in-depth understanding of genetic susceptibility to Parkinson's disease, and provide a scientific basis for risk predicting and preventing of Parkinson's disease.