肿瘤切除术后的区域化疗对于癌症治疗的预后至关重要，如何实现局部可控给药和实时监测药物释放仍是亟待解决的难题。针对这些难题，本项目拟设计合成DNA-稀土上转换发光纳米粒子（UCNP）复合水凝胶，作为新型的生物医用高分子水凝胶载药系统。以DNA水凝胶为抗癌药物阿霉素（DOX）的载体，充分发挥DNA水凝胶结构精准可控、功能精确可调的优势，实现药物在病灶部位的可控释放；利用DOX释放过程中UCNP上转换发光信号相对强度的变化，实现定量、实时监测药物释放。我们创制的新型DNA-稀土生物医用高分子水凝胶系统能够解决深位置病灶的局部可控给药和高灵敏实时监测的难题，实现局部给药-实时监测一体化，为个性化治疗奠定重要基础。

Regional adjuvant chemotherapy after tumor resection is crucial to the prognosis of cancer treatment. However, it remains a grand challenge that how to simultaneously monitor the drug release during the localized delivery process. In this proposal, to address these challenges, we design a new bio-medical polymeric hydrogel, which is a complex of DNA hydrogel and rare earth upconversion nanoparticles (UCNP). As the carrier of anticancer drug doxorubicin (DOX), DNA hydrogel possesses superior advantages including precisely controllable chemical structures and functions, thus achieving controlled drug release in the lesion sites. The UCNP luminescence signal is employed to quantify and monitor the drug release in deep tissues. Our DNA-rare earth biomedical polymer hydrogel system integrates the localized controlled drug delivery and real-time monitoring with high sensitivity. We envision that our system will establish an important foundation for the clinical individualized regional adjuvant chemotherapy.