复杂机械装备的可靠性设计是一个多学科耦合、多系统交互、时变、非线性的问题，本项目以复杂机械装备可靠性优化设计为工程背景，拓展出多物理场耦合下基于虚拟样机技术的复杂机械装备可靠性设计优化方向，凝练出其中的关键科学问题加以研究，主要包括：多源混合不确定性下多物理场耦合分析方法、虚拟样机技术框架下数据融合技术和基于机器学习的失效物理建模方法、研究基于仿真方法的机械零部件的时变可靠性优化设计方法、复杂机械装备的多级层次型灵敏度分析方法、 基于层解分析法的复杂机械装备的时变可靠性优化设计方法，建立复杂机械装备的多级层次型时变可靠性优化设计系统，为进行复杂机械装备的时变可靠性优化设计提供软件工具。本项目解决复杂机械装备的时变可靠性优化设计的关键问题，为进行复杂机械装备的时变可靠性优化提供有效途径，具有重要的学术意义，也有现实的应用前景。

Reliability based design of complex mechanical equipment is a multidisciplinary coupled, multi-system shared,time-dependent and nonlinear Problem. This new project proposal is based on reliability design optimization of complex mechanical equipment, and it extends existing research by considering time-dependent reliability design optimization for complex engineered systems under multi-physics coupling based on virtual prototyping technology. In this project, we will research the key scientific problems, which mainly includes research on multi-physics coupling analysis method considering multi-source mixed uncertainty,physics of failure modeling based on data fusion technology and machine learning method under the framework of virtual prototyping technology, simulation-based time-dependent reliability design optimization for engineered components, multilevel hierarchical sensitivity analysis for complex engineered systems, analytical target cascading method based on time-dependent reliability design optimization for complex engineered system. The multilevel hierarchical time-dependent reliability design optimization system and software for complex mechanical equipment are developed and will be provided to research sponsors. The project solves the key scientific problems of time-dependent reliability design optimization for complex mechanical equipment, provides an effective approach for time-dependent reliability design optimization of complex mechanical equipment with important academic contributions and practical application prospect.