生物钟节律是所有生物重要的生理现象，它的失调会引起节律紊乱而导致多种疾病，因此是生命科学研究的热点。microRNA（miRNA）作为生物体内基因转录后调控的重要分子，对多种生理行为过程发挥着重要的调控作用。在黑腹果蝇中，我们利用遗传学筛选实验，控制miRNA特异在大脑钟神经元的表达，初步发现miR-263a和miR-263b参与调控昼夜活动节律。本项目将在此基础上详细研究miR-263a和miR-263b对生物钟节律的调控，以及具体调控的分子机理。该项目的实施将为生物节律的认知提供重要的理论依据， 对学科的发展也具有重要的科学意义。

Circadian rhythm is an important physiological phenomenon for all lives on the earth. The rhythmic disorder of biological clock can result in a variety of diseases. Therefore, the circadian rhythm is currently hot and focus area of life science studies. MicroNRA(miRNA), as post-transcription regulation molecules, play an important role in many physiological processes. In Drosophila melanogaster, we performed a genetic screens in which expression of miRNAs were limited to brain clock neurons. We found that miR-263a and miR-263b involoved in regulating circadian rhythm. On this basis, we will further explore detailedly the function of these miRNAs for circadian rhythm regulation as well as their molecular mechanism. This will supply important theoretical basis for the understanding of biological rhythms, and there is an important scientific significance for discipline development.