牙体组织的脱矿客观反映牙齿健康状况，其早期无损检测可对龋患部位再矿化处理，将“破坏性治疗”提前到“可逆性预防”阶段，具有重要的临床和社会意义。本项目利用脱矿对各向异性牙体组织有序性结构的破坏，在获取离体牙后向散射光的Mueller矩阵基础上，研究利用Mueller矩阵分解参数描述各向异性牙体组织二向色衰减、相位延迟、退偏等分离物理效应的可行性，并结合横向显微放射TMR技术构建基于Mueller矩阵分解参数评价牙体组织脱矿程度的定量化指标。具体研究内容包括（1）各向异性牙体组织的偏振光散射规律（2）牙体组织后向散射光的Mueller矩阵测试（3）Mueller矩阵分解及脱矿情况的定量化表征（4）牙体组织早期脱矿的Mueller矩阵分解参数定量评价验证。本研究从牙体组织的结构特征表征出发，构建基于Mueller矩阵分解参数的脱矿定量化评价指标，探索一种客观灵敏的牙体组织早期脱矿无损诊断技术。

Demineralization of dental tissue objectively reflects the health status. Early nondestructive detection provides the possibility to remineralize the carious tissue, having a great significance to the clinic and society. Based on the impact of demineralization on the ordered structure of anisotropic dental tissue, the Mueller matrix expressing the media polarizing effect is experimentally obtained and then the decomposition of Mueller matrix is computed to describe the separated physical effect such as diattenuation, phase retard and depolarization. The aim is to build the evaluation index quantitatively using decomposition coefficient for demineralization combined with the transverse microradiography. The studies involve (1)Law of polarized light scattering in anisotropic dental tissue (2)Mueller matrix measurement of backward light of teeth surface (3)Mueller matrix decomposition and characterization of demineralization (4)Validation of decomposition coefficient to quantify early demineralization. This research is carried out from the view of anisotropic structure property, and an invasive diagnostic method and quantitative coefficient are expected to be obtained. The noninvasive method to detect demineralization objectively and sensitively is to be explored.