基于UV-LED光触发碱增殖反应的巯基-烯光化学点击体系

巯基-烯点击化学作为一类最具发展前景的无金属催化点击反应，在表面修饰、微型器件制造、纳米材料、网状聚合物、聚合物功能化、有机合成等领域获得了广泛应用。本项目针对巯基-烯点击反应缺少较理想可控方法的缺陷，拟通过把光触发碱增殖反应和安全环保的UV-LED光聚合方式同时引入巯基-烯点击反应中，构筑一个具有较强普适性的高效光控的胺催化方法，即基于UV-LED光触发碱增殖反应的光化学点击法。研究内容如下：合成一系列性能独特的UV-LED光产碱剂和碱增殖剂；建立UV-LED光触发碱增殖反应，调查其特殊的产胺动力学；开展UV-LED光触发碱增殖催化的巯基-烯点击反应的基础研究；利用建立的方法制备各种高可控性材料、光屏蔽材料和生物材料。该课题的完成将为巯基点击化学提供高效普适性的可控方法，并大大拓展其应用空间。这无论从学术研究或实际应用的角度来说都是一项很有意义的工作。

The thiol-ene reaction as the most promising and metal-free click reaction, has been widely employed in surface modification, microdevice fabrication, nano-material, network polymer, polymer functionalization, and organic synthesis. However, the absence of the ideally control method has plagued its development. In this project, a new photo-click method based on UV-LED photopolymerization and photo-triggered base proliferation reaction, as a universal and highly effective amine catalytic method, is proposed. The main studies are as follows (i) synthetize a series of functional UV-LED photobase generators and base amplifiers; (ii) establish UV-LED photosensitive base proliferation reaction, and investigate the special dynamic process; (iii) develop the basic research on UV-LED photo-triggered base proliferation controlled thiol-ene reaction; (iv) evaluate the applicability of this method to the synthesis of high control materials, photo-screened materials, and biomaterials. Consequently, the project, as a basic research, is of great academic significance and application prospect.