糖尿病大血管病变(冠心病、脑血管病)严重威胁人们的生命和健康。低密度脂蛋白受体11(Low-density lipoprotein receptor relative 11，LR11) 在动脉硬化动物模型动脉斑块内膜平滑肌细胞中表达增高，其血清水平与糖代谢紊乱的生化指标及动脉硬化危险因素相关，在冠心病、2型糖尿病及阿尔茨海默病中呈高值。最近研究显示，幽门螺杆菌(Helicobacter pylori，Hp)感染与冠心病、糖尿病及脑血管性痴呆危险有关，但目前尚存很多争议，与糖尿病大血管病变的关系也不清楚。本课题组的前期研究发现血清可溶性LR11水平与2型糖尿病及其颈动脉内膜中层厚度相关，预试验发现Hp感染与一般人群的颈动脉内膜中层厚度密切相关，与2型糖尿病颈动脉内膜中层厚度有相关趋势。本课题拟探讨Hp感染和LR11在糖尿病大血管病变发生发展过程中的作用，为防治糖尿病大血管病变提供新思路。

Diabetic macrovascular disease (coronary disease, cerebral vascular disease) poses a great threat to life and health in humans. Low-density lipoprotein receptor relative 11 (LR11) is highly expressed in intimal smooth muscle cells at the intima-media border in the plaque area of experimental models of atherosclerosis. The serum soluble LR11 concentration is associated with biochemical markers representing disturbed glucose metabolism and atherosclerosis risk factors, and increased in coronary heart disease, diabetes mellitus and Alzheimer disease as well. Recent researches have shown that Helicobacter pylori (Hp) infection is related to the risk of coronary disease, diabetes mellitus and cerebral vascular dementia, but there is still much controversy. Furthermore, the relationship between Hp infection and diabetes macrovascular disease is not clear either. Our previous research showed that serum soluble LR11 concentration is associated with carotid artery intima-media thickness (IMT) in type 2 diabetes mellitus, our preliminary research showed Hp infection is closely related to carotid artery IMT in the general population and tended to have relationship with type 2 diabetes mellitus. The aim of this research is to explore the roles of Helicobacter pylori infection and LR11 in the pathogenesis and development of diabetic macrovascular disease, which provide new insights into prevention.