SLE确切病因及发病机制不明，紫外线是诱发和加重SLE最重要的环境因素。前期研究发现UVB照射汉族SLE患者外周血单个核细胞后miR-125b-5p表达下降,自噬基因UVRAG表达升高，增加细胞自噬。高海拔对SLE的临床、器官受累产生不同影响。那生活在相同高海拔地区的藏族、纳西族和汉族SLE发病情况是否相同？藏族在遗传学上有独特特征，主要居住于高海拔、低氧、紫外线强的地区，理论上更易诱发SLE。目前未见藏族人群SLE发病的研究报道。我们推测藏族因特殊的遗传学特点和生活环境，SLE的流行病学特征和临床表现可能与同地区的纳西族和汉族有所差异。为此，本研究将应用流行病学、分子生物学、生物信息学研究云南省迪庆香格里拉地区相同环境下藏族、纳西族和汉族人群SLE发病情况、临床特点；研究紫外线照射、自噬等在藏族SLE患者中的作用机理，为进一步阐明环境和遗传因素在SLE的发病机制和合理防治提供理论基础。

The exact etiology and pathogenesis of SLE are unknown. Ultraviolet radiation is the most important environmental factor in inducing and exacerbating SLE. Our previous studies showed that the expression of miR-125b-5p decreased and the expression of autophagy gene UVRAG increased ，activate cell autophagy after UVB irradiation on peripheral blood mononuclear cells of SLE patients of Han nationality. High altitude has different effects on the clinical and organ involvement of SLE. Is the incidence of SLE the same in Tibetan, Naxi and Han nationalities living at the same altitude? The Tibetans have unique genetic characteristics. They mainly live in areas with high altitude, hypoxia and strong ultraviolet rays, in theory, more likely to induce SLE. However, there is no report on the incidence of SLE in Tibetan or Naxi population. We speculate that the epidemiological characteristics and clinical manifestations of SLE in Tibetan nationality may be different from those of Naxi and Han nationality in the same area due to their special genetic characteristics and living environment. Therefore, this study will apply epidemiology, molecular biology and bioinformatics to study the incidence and clinical characteristics of SLE in Tibetan, Naxi and Han ethnic groups in the same environment in Diqing Shangri-La area of Yunnan Province. To study the mechanism of ultraviolet radiation and autophagy in Tibetan patients with SLE and to provide a theoretical basis for further elucidation of environmental and genetic factors in the pathogenesis and rational prevention and treatment of SLE.