呼吸中枢驱动在夜间哮喘及睡眠呼吸暂停中的应用价值

哮喘是一种常见的慢性呼吸道疾病，严重影响人类健康。哮喘的死亡多发生于夜间，其风险是白天的5至6倍。夜间哮喘是一独立类型还是疾病进展控制不良的表现目前尚无定论，但可认为是影响生活质量，损害肺功能以及影响预后的重要因素。然而目前在评估夜间哮喘的手段上遇到瓶颈，其局限于肺功能与问卷调查，前者不实际而后者不准确，不利于对夜间哮喘病情的评估，也限制了对夜间哮喘机制的探讨与疗效评估。本课题在前期研究的基础上，突破技术瓶颈，首要目标是建立一项客观且可持续有效评估夜间哮喘的技术，即呼吸中枢驱动有效性；并进一步探讨呼吸中枢驱动在OSA诱发哮喘夜间急性发作的发生机制，以及CPAP治疗OSA合并哮喘的疗效及其机制中的作用。

Asthma is common chronic airway disease, which seriously affect human health.The majority of deaths due to asthma mainly occur at night, with a risk of five to six times than at daytime. Whether nocturnal asthma is an independent type or poorly controlled asthma is still unclear, but it is considered as an critical factor affecting quality of life and prognosis, and impairing lung function. Currently, we meet difficulty to accurately and appropriately identify nocturnal attacks in patients with asthma. Lung function and questionnaires are the common approaches of assessing nocturnal asthma, but both have defects either impractical or inaccurate, which make difficulty to perform study on mechanism of nocturnal asthma and efficacy assessment of novel treatment for asthma. In this program, we will establish a novel approach, efficiency of neural respiratory drive, to assess nocturnal asthma base on a series of our previous studies; and further explore the effect of neural respiratory drive on the mechanism of OSA induced nocturnal asthma and efficacy assessment of CPAP treatment for OSA combined asthma.