减少内固定手术时感染的发生，改善临床，是目前制约骨板等植入物在医学领域应用的主要瓶颈。课题提出在骨板表面设计不同仿生织构思路，对织构进行参数化设计，采用飞秒激光加工技术在骨板表面加工仿生织构，利用微弧氧化技术制备出组织形貌和几何结构可控的多孔结构陶瓷，观察微弧氧化过程中磷灰石和TiO2多孔复合陶瓷形成的动态演化过程，澄清骨板表面仿生织构诱导多孔结构形成机制，揭示织构诱导形成多孔陶瓷的几何结构拓扑特性；在孔穴内浸涂具有杀菌缓释作用的聚维酮碘杀菌药物，通过HANKs人工体液体外实验和BALB/c小鼠、山东青山羊体内试验，观察骨板表面多孔结构载带杀菌药物实现输运缓释的动态演变过程，推导药物在多孔结构陶瓷内的速度、流量和压力梯度表达式，构建多孔结构上载聚维酮碘实现储运缓释的流体动力学模型，澄清多孔陶瓷载带药物靶向储运缓释的机制，为骨板在内固定手术时的可靠性使用提供理论基础支撑。

It is well known that the bacterial infection during internal fixation operation of bone plate restrict its medical application. Our researches will allpy micro texture technology to change the surface microstructure of bone plate. Femtosecond laser processing technology is used to manufacture micro texture. And, micro-arc oxidation technology is used to fabricate porous structure ceramic layer. Based on the dynamic evolution formation process observation of hydroxyapatite and TiO2 composites ceramic structure, the mechanism of texute on bone plate induced on formation porous structure ceramic is clarified. And, topological structure characteristic of porous structure is revealed. At the same time, some sterilized medical drugs such as povidone iodine are infiltrated into the porous ceramic layer. Based on the vitro experiment in HANKs artificial simulated body fluid and Vivo surgery of BALB/c mouse and Shandong grey goat, the dynamic evolution process of drug targeted delivery and controlled-release are observed. The non-newtonian fluid mechanics constitutive model for texture drug targeted transport and releasing is put forward by analysising flow field distribution rule of texture drug delayed releasing and transporting under different bone healing stages. The model buliding will offer the basic theory for bone plate application.