癫痫是由于脑神经元异常放电所引起的一种慢性病，手术切除病灶是最有效的治疗方法。本课题针对癫痫术前病灶精确定位的需求，研究面向癫痫监测的颅内高频振荡神经脑电信号高速无线采集微系统的关键技术。通过建立传感电极和生物体组织接触电学特性模型，探索全集成具有休眠和快速启动技术的前置放大器设计方法；通过建立超宽带射频信号在生物组织中的信号衰减模型，研究低功耗、高频谱效率、低复杂度脉冲超宽带信号发射电路以及具有相位纠偏技术的超宽带非相关接收电路的设计方法。通过上述研究，提炼出脑电信号记录前端链路的低噪声、低功耗、宽频带设计理论以及透过人体组织的超宽带高速收发链路设计理论。拟实现植入微系统采集通道数256个，物理层传输速率不低于300Mbps，单通道模拟带宽不低于5kHz，系统功耗低于20mW，并对所设计的植入系统和关键模块进行在体动物实验验证。

Epilepsy is a chronic disease caused by abnormal discharging of cerebral neuron, excision lesions through surgery is the effective therapeutic method. Aiming at the requirements of epilepsy accurate positioning, this project intends to study the key techniques of high-speed wireless acquisition microsystem of intracranial high-frequency-oscillation eletroencepalograph (EEG) for epilepsy detection. Based on electrical characteristics modeling of the sensing electrodes and the contacted biological tissues, the design method of fully integrated preamplifier with dormant and quick start techniques will be explored. And the design method of low-power, high frequency spectrum efficiency, low-complexity impulse ultra-wide band (UWB) transmitter and UWB non-correlation receiver with phase correction technique will be studied based on the signal attenuation model of UWB signal transmitted in the biological tissues. With the above research, the design theory of low-noise, low-power and wideband for the EEG recording front-end chain as well as the design theory of UWB for high-speed transmitting and receiving chains penetrated the human tissues will be summarized. Finally, the implantable microsystem with 256 acquisition channels is intended to be realized, the physical layer transmission rate is higher than 300 Mbps, the bandwidth of each channel is greater than 5 kHz and the power consumption of system is lower than 20 mW. The microsystem and key modules presented in this project will be planted for animal experimental verification.