氨基糖苷类抗生素水溶性强，难以从环境和食品样品中对其进行提取和富集，是复杂基质中对其残留量进行有效监控的瓶颈问题。设计和制备对此类化合物具有特异识别性的捕集材料是解决这一问题的根本途径。笼型倍半硅氧烷(POSS)是易被化学修饰的纳米级结构单元，本项目拟以八乙烯基-POSS为修饰平台，整合巯-烯加成和（活性／可控）自由聚合反应，构筑“团队亲和”型功能化磁性纳米材料。利用新材料识别性的多维组合及磁分离的优势，实现氨基糖苷类化合物在复杂基质中的高选择性萃取，以此建立准确、灵敏的残留分析检测技术平台。

Aminoglycosides (AGs) are hardly extracted and enriched from complex matrices owing to their highly hydrophilic properties.This has become a bottle-neck problem in AGs residues analysis in complex matrices including food and environmental samples. Therefore, design and synthesis of trapping materials with specific recognition for AGs would be emphasized. Polyhedral oligomeric silsesquioxanes (POSS) are nanosized building blocks with rich functionalizable sites. This program would propose various modifications on vinyl-POSS to fabricate a series of “teamed affinity” type magnetic nanoparticles by integrating with thiol-ene addition reaction and (living/controlled) free radical polymerization. The combinations of materials' multi recognitions as well as the facility of magnetic separation could make high selectivity extraction of AGs from complex matrices feasible, thereby establishing applicable analytical platforms for the determination of AGs residues with good accuracy and high selectivity.