急性脑缺血具有高致死率、高致残率的特点。目前对于急性脑缺血治疗手段十分有限。因而，临床上迫切需要有新的干预手段以改善卒中患者受损的脑和神经功能。内皮祖细胞（EPCs）的移植治疗将可能是一种非常有前途的治疗卒中的方法。然而，缺血性疾病患者往往合并冠心病、糖尿病、高血压等基础疾病，导致EPCs移植后效果不及预期。因此，如何促进移植的EPCs在缺血组织中存活是EPCs移植治疗的关键。课题组的前期相关研究表明，当归补血汤可改善动脉粥样硬化动物模型的外周EPCs数量，促进EPCs集落形成、黏附、迁移和体外血管形成的能力。本课题组在前期研究的基础上，探讨机体微环境对EPCs移植疗效的影响，以及当归补血汤联合EPCs移植治疗的协同增效及机制，为脑缺血探索一条全新的治疗模式。这一研究将为当归补血汤联合EPCs移植治疗急性脑缺血的临床转化提供新的理论和实验依据。

Acute cerebral ischemia has the characteristics of high lethality and high disability. At present, the treatment of acute cerebral ischemia is very limited. Thus, there is an urgent need for new interventions to improve brain and neurological function in stroke patients. Transplantation of endothelial progenitor cells (EPCs) may be a very promising method of treating stroke. However, ischemic disease patients often combined with coronary heart disease, diabetes, hypertension and other underlying diseases, leading to EPCs after transplantation is less than expected. Therefore, how to promote the survival of transplanted EPCs in ischemic tissue is the key to EPCs transplantation. Previous studies in the study group showed that Danggui Buxue Tang can improve the number of peripheral EPCs in animal models of atherosclerosis and promote the ability of EPCs colony formation, adhesion, migration and in vitro angiogenesis. On the basis of previous research, this study explored the effect of microenvironment on EPCs transplantation and the synergistic effect and mechanism of Danggui Buxue Tang combined with EPCs transplantation, and explored a new treatment model for cerebral ischemia. This study will provide a new theoretical and experimental basis for the clinical transformation of Danggui Buxue Tang combined with EPCs transplantation for acute cerebral ischemia.