微生物诱导T细胞免疫应答在口面部肉芽肿病发病中作用

口面部肉芽肿病（oro-facial granulomatosa, OFG）的病因和发病机制尚不清楚，目前认为可能的因素包括易感基因、食物过敏、牙科材料过敏、感染和免疫因素，是一种迟发超敏反应。国内外临床观察及初步研究发现，认为该病与牙源性感染有一定关系，牙体治疗后部分GC患者的病损减轻或者消失，但是具体相关性及其机制尚不清楚。本研究拟采用克隆测序、高通量测序等方法，从GC的微生物因素出发，检测组织和唾液中微生物多样性，分析其微生物种属的差异和一致性，初步揭示GC的微生物病因和发病机制，为GC的发病机制提供新的理论依据，为治疗开辟新的途径。

The etiology and pathogenesis of oro-facial granulomatosa (OFG) are known, several theories link OFG with heredity, food substances, dental materials, microbiological agents and immune response. The pathogenesis of OFG points towards a delayed hypersensitivity. Current research and clinical observations show that OFG has a certain relationship with odontogenic infection. The patients who accept endodontic therapy gain improvement or total healing, but the reason is uncertain. This project will investigate the pathogenesis of OFG from the aspects ofmicroorganisms by cloning sequencing or high throughput sequencing. The abundance and diversity of microorganism will be detected. The research results will also give new insight to understand chronic inflammation and provide evidence for the therapy of OFG.