HAART治疗对艾滋病免疫功能重建有其局限性，如治疗后只有60%病人可以做到免疫功能重建，而是否能恢复到正常水平尚未证实；再生的CD4+CD45RA+T细胞甚至在HIV复制时就被抗病毒药完全抑制；这意味着病人可能出现无药可用的境地。因此，寻找免疫重建的新策略和新方法成为目前国际艾滋病研究的热点。本研究通过观察中医药联合HAART疗法对艾滋病患者免疫重建胸腺近期输出功能和TCR Vβ谱系利用特点的影响，从改善胸腺近期输出功能和提高免疫力的角度出发探讨中医药在人体内对免疫系统的作用机制，找出中西医结合改善艾滋病患者免疫功能的可能靶点，为中西药合用治疗艾滋病提供临床应用的基础支持；探索胸腺功能的改变和疾病进程的内在联系；为我国艾滋病的治疗提供数据支持；为开发艾滋病疗效评价免疫学指标提供理论依据。

HAART (Highly Active Antiretroviral Therapy) has its limitations in HIV/AIDS immune function reconstitution. For example, only 60% patients can realize the reconstitution of immune function after receiving treatment and whether they can return to the normal level is unproved; the regenerated CD4+CD45RA+T cells are completely inhibited by antiviral drugs during the replication of HIV; and this means that the patients may encounter the dilemma of no cure. Therefore, the hotspot for current international AIDS research is to search new strategies and new methods for immune function reconstitution. By observing the influence on recent output function of thymus through the immune reconstitution of AIDS patients and on utilization characteristics of TCR Vβspectrum through the combination of traditional Chinese medicine and western medicine, this research aims to discuss the action mechanism of traditional Chinese medicine and western medicine for immune system in the human body from the recent output function of thymus and the immunity enhancement, find out the possible targets for improving the immune function of AIDS patients through the combination of traditional Chinese medicine and western medicine and provide basic support for clinical application of the combination of traditional Chinese medicine and western medicine for AIDS treatment; explore the internal relations between the change of thymus and the disease process; provide data support for AIDS treatment in China; and provide theoretical basis for developing immunological indicators for the evaluation of HIV/AIDS curative effect.