兽药残留是引起众多食品安全问题最主要的因素之一。磺胺(SAs)类抗生素因价廉、抗菌谱广、使用方便被大量用于畜产品养殖。因不规范或超剂量用药等主客观因素导致SAs在动物组织、脏器、蛋等部位的过量蓄积，对人体健康造成了极大的危害，有必要加强其检测和监控。.灵敏、高效快捷的荧光探针检测技术是保障食品安全的重要手段，为近年来国内外研究的热点。本项目针对食品中残留磺胺兽药的结构特点，通过苯硫酚与苯磺酰基的碳硫键之间发生的芳基亲核取代（SNAr）反应释放出SO2，生成的SO2在体系中转化为HSO3-；构建并制备得到反应型水溶性的D-pi-A结构荧光探针用于HSO3-的靶向检测，进而实现磺胺类兽药残留高效快捷的检测。项目研究以期能获得高灵敏度、响应速度快、结构新颖的反应型靶向HSO3-荧光探针，利用检测HSO3-间接实现磺胺类兽药残留的快速检测建立新方法和技术平台，具有良好的应用前景和重要的现实意义。

Veterinary drugs residue is one of the most important factors affecting the food security. Sulfonamides (SAs) antibiotics have been widely used in husbandry due to their low-cost, broad antibacterial activities and convenience. The excessive accumulation of SAs in animal tissues or organs or eggs, which caused by subjective and objective factors such as non-standard or over-dose consumption, has been affected human health extremely. Thus, it is necessary to detect and regulate of SAs forcefully. .Exploiting of detection technologies with efficient, rapid and sensitive characteristics is an vital technical means to ensure food security, and it is also the focus of research in recent years over the world. Here, a series of reaction-based water-soluble fluorescent probes with D-pi-A configuration were prepared for detection of the bisulfite which was originated from sulfur dioxide, where the sulfur dioxide was generated via nucleophilic aromatic substitution reaction between phenylthiophenol derivatives and the carbon-sulful bond of benzsulfonyl in the sulfonamides. As a result, the rapid and high efficiency detection of sulfonamides residue within animal products was achieved based on the content of the bisulfite measured through the reaction-based fluorescent probes. The goal of the project is to develop some novel of reaction-based fluorescent probes for the detection of bisulfite with high sensitivity and rapid response as well as to create a new method and to establish a technical platform for rapid and quantitative detection of sulfonamides residue by means of gauging of the bisulfite. It has good application prospects and great practical significance.