螺旋聚合物超薄膜的手性分离性能研究

许多药物、香精等均是外消旋混合物，但通常仅有一种异构体起作用而另一种却会产生副作用。本项目以螺旋聚合物为研究对象、制备非对称超薄膜为手段、实现手性分离为目的，全面了解螺旋聚合物的形成过程及其识别手性分子的能力、手性分子在薄膜中的传递本质；探讨聚合物侧链基团性质与螺旋结构之间的关系，确定侧链确切的排列方式；引入超分子聚合物刷，深入研究螺旋及超螺旋的形成过程；考察螺旋聚合物与对映异构体之间的作用差异，明确空间结构、弱相互作用在其中的作用，阐明螺旋聚合物识别手性分子的机制；探索以螺旋聚合物为功能层、多孔膜为基质层的非对称超薄膜的制备方法，考察螺旋结构、功能层厚度及孔径等膜性质对手性分离的影响，揭示这类膜实现手性分离的机理。本项目的完成可以明确形成螺旋、超螺旋聚合物的本质、过程及其控制因素，通过改变螺旋结构调控其与手性分子的亲和力而实现手性分离，将螺旋聚合物开发为一种新型的手性分离材料。

Many drug, pharmaceutical and flavor compounds are racemic mixture. However, only one of the two enantiomers performs the required action, while the other one may cause unwanted side effect. This project focuses on the helical polymers, prepares the asymmetric hyperthin membranes and aims at the chiral separation, comprehensively understand the formation process and recognizing ability to chiral molecules of the helical polymer and the transfer essence of enantiomer in the asymmetric hyperthin membranes; discusses the relationship between the pendant natures of polymers and the helical structures and determines the arranging mode of the side groups; introduces the supramolecular polymeric brush via self-assembly and delicately examines the constructing process of the helix and the superhelix; explores the different interactions of the helical polymers with two enantiomers and establishes the effect of the steric hindrance and weak interaction on them; thoroughly explores the recognizing principle of the helical polymer to chiral molecules; examines the preparing method of the asymmetric hyperthin membranes by means of depositing or anchoring the helical polymer on the porous substrates; investigates the effect of membrane properies, such as helical structure, the thickness of the functional layer and the porous size, on the chiral resolution; discovers the mechanism that the asymmetric hyperthin membranes including helical polymers facilitate the chiral resolution. The completion of this project will determine the nature,the process and the dominant factors of the helical and/or superhelical polymers, modify the affinity of the hlical polymer for chiral molecules by means of the adjustment of the helical structure in order to implement chiral sepraration and finally develop a new helical polymer material for chiral resolution.