研究表明血小板不仅在凝血和维持血管完整性方面具有至关重要的作用，而且还参与了肿瘤，炎症等多个生理和病理状态。最近的研究表明血小板中含有大量的miRNA,并且血小板可以释放大量的包裹miRNA的microvesicle。前期的研究表明miRNA对基因的表达调控发挥重要作用，参与包括肿瘤等在内的各种生理病理过程。此外microvesicle运输的miRNA在细胞间通讯过程中也扮演了十分重要的作用。基于此，在本项研究中我们将以肺癌为模型，首先揭示肺癌病人血小板内特异性的miRNA，以及探讨这些miRNA在肺癌发生发展过程中的重要作用。其次，我们将利用体内和体外实验，揭示血小板释放的microvesicle中的miRNA在促进肺癌转移和免疫逃逸过程中的作用。通过本项研究，我们将揭示血小板以及其释放的microvesicle在肺癌发生发展过程中的生物学功能，为肺癌的诊断和治疗提供新的思路和途径。

Studies have shown that platelets didn’t only have a crucial role in coagulation and vascular integrity, but also involved in lots of physiological and pathological states, such as tumors and inflammation. Recent studies indicated that platelets contained lots of miRNA, and could also release large parcels of miRNA packged in microvesicle. Early studies showed that miRNA plays an important role in regulation of gene expression, and participats in a variety of physiological and pathological processes. In addition, miRNA transported by microvesicle also play a very important role in intercellular communication. Based on this, in this study we will firstly identify the specific miRNA in platelet of lung cancer patient, and explore the role of these miRNA in the development process of lung cancer. Secondly , we will use in vivo and vitro experiments to reveal the role of miRNA derived from the platelet released microvesicle in tumor metastasis and immune escape. Through this study , we hope reveal the biological function of platelets and microvesicle derived from platelet in the lung cancer, and , provide new ideas and approaches for the lung cancer diagnosis and treatment .