药品及个人护理品中的外源性雌激素，其母体及代谢产物未能被污水厂有效去除而直接进入环境。生物体暴露后，可以干扰其体内正常的内分泌功能，具有潜在的健康及生态风险。本项目拟以外源性雌激素类物质为目标污染物，通过电子束辐照技术处理，分析此类污染物降解过程中瞬态及稳态产物特性情况，进一步结合光解特性，探讨相关降解反应途径，并分析研究实际环境因素对活性粒子及降解效果的影响，深入探寻相关降解反应过程中高活性粒子与污染物之间的作用机制，结合理论化学阐明外源性雌激素的电子束辐照作用机理，为其环境光解行为及辐照降解应用提供理论支撑。在作用效果评估方面，以分子生物学为研究手段，从分子水平、细胞水平探索污染物辐照降解前后的毒性变化及作用机理，提出一种复杂环境中，对该类新型污染物辐照降解效果及毒性评估方法。研究成果将为研究城市水体中外源性雌激素类物质环境转化行为、环境风险评估和高级氧化降解机理提供理论支撑。

Xenoestrogens(XEs) from pharmaceuticals and personal care products have caused serious environmental pollution with potential ecological and human health risk because of the limited degradation in sewage treatment plants. In this project, the XEs are degraded by electron beam irradiation and photolysis. The mechanism of interaction between highly active particles and pollutant molecules in the process of degradation is studied by the combination of transient and steady-state technologies. The effect of environmental factors on electron beam irradiation is discussed. Combined with theoretical chemistry, the degradation mechanism of XEs by electron beam irradiation and photolysis is clarified. The mechanism and changes in toxicity of pollutants before and after irradiation degradation are explored by molecular biology. A new structure identification and toxicity assessment of products of XEs degraded in complex condition are proposed. The theoretical study of environmental transformation behavior, environmental hazards risk and advanced oxidation degradation mechanism of XEs in urban water will be provided.