抗痛风活性肽的发现、结构&功能、机制研究

痛风已经成为第二大代谢性疾病，给患者造成严重的生理负担。现临床上多以药物控制为主，但常用药禁忌症繁多且毒副作用频发，加之各种因素导致痛风患者数量急剧增长，使得新型抗痛风药物的发现显得极为重要和紧迫。多肽分子种类丰富、作用多样且具有极高的特异性和高效性，在人类疾病治疗方面具有其不可忽视的作用，但目前国内外抗痛风活性多肽的研究报道非常稀缺。项目组发现云南地方特产大米水提物中存在降尿酸活性肽类分子群（其中之一已经正式发表于Journal of Agricultural and Food Chemistry），在此基础上，本项目将运用分离纯化技术结合整体动物水平活性追踪，从该大米水提物中鉴定具有抗痛风的活性多肽分子群，开展其结构与功能研究、检测其抗痛风活性、进行所涉及的机制探索。本项目的顺利实施有望为新药研发提供具有自主知识产权的高效抗痛风活性多肽分子群，具有一定的临床应用前景。

Gout has become the second largest metabolic disease, causing serious physiological burden to patients. At present, drug control is the main method in clinical practice, but there are many contraindications and side effects in common use. In addition, various factors lead to a sharp increase in the number of gout patients, which makes the discovery of new anti-gout drugs extremely important and urgent. Peptides are abundant, diverse and highly specific and efficient. They play an important role in the treatment of human diseases. However, there are few reports on the research of active anti-gout peptides all over the world. In our previous research, great diversity of urate-lowering peptide were traced in the water extract of Yunnan local rice (one of them was published online in Journal of Agricultural and Food Chemistry). This project will identify the active peptide molecular group with anti-gout activity from the rice water extract by separation and purification technology combined with the activity tracking on animal level, carry out their relationship between structure and function, determine their anti-gout activity, and explore the mechanism involved. The successful implementation of this project is expected to extend our research interest in this field, and provide anti-gout peptide molecular group with independent intellectual property rights for new drug research and development.