胰腺癌的高侵袭转移性仍然是临床治疗的难点。研究认为lncRNA可作为ceRNA可调控microRNA及下游靶基因的表达，在众多的肿瘤发生、侵袭和转移中有着重要的作用。我们前期的研究中发现lncRNA-FGD5-AS1在胰腺癌患者中表达上调，并且调控miR-137的表达进而影响着胰腺癌侵袭转移特异基因的表达。因此，我们提出研究假设，FGD5-AS1作为ceRNA与miR-137相互作用，引起下游靶基因Calpain2的表达上调，通过蛋白酶解FAK、Talin促进黏着斑的周转，进而促进胰腺癌的侵袭转移。

Pancreatic cancer is highly invasive, which is still a difficulty for clinical treatment. Recent research found that the lncRNA can be finctions as ceRNA to regulate the expression of miRNA and downstream target genes，miRNAs play a central role in the occurrence, invasion and metastasis of numerous tumors.Our preliminary study suggests that lncRNA FGD5-AS1 was high expression, which regulate the expression of the miR-137, and then affects the expression of specific genes for metastasis of pancreatic cancer. Therefore, we put forward the research hypothesis, FGD5 - AS1 function as ceRNA, competing with miR-137, to promote the expression of target genes Calpain2, which protease solution FAK and Talin promote focal adhesion turnover, ultimately promote the invasion and metastasis of pancreatic cancer.