内分泌干扰物（EDCs）是一类在环境中赋存浓度虽低但毒性较大的特殊污染物，近年来受到国内外学者的广泛关注。城市污水处理厂是环境中EDCs污染的主要来源之一，也是控制EDCs向环境中排放的重要环节。本项目拟以雌激素和酚类这两类典型EDCs为对象，通过对其自由态和结合态的全面考察，研究其在污水处理厂中的分布特征、迁移转化规律、降解机理及排放风险。首先，基于色谱-质谱技术，开发可同步检测污水及污泥两相中EDCs自由态及结合态的检测方法；通过调查采样，掌握EDCs在三种典型污水处理工艺（A/O、A/A/O、氧化沟）中的分布特征与迁移转化规律，明确其重点去除工段及降解机理，解析外排出水与剩余污泥中EDCs的种类及形态；通过对相关样品的雌激素干扰效应检测，评价城市污水处理厂EDCs的潜在环境风险。本项目的研究结果将揭示城市污水处理厂中EDCs的分布、迁移转化、归趋及风险，为处理工艺的优化运行提供依据。

Endocrine disrupting chemicals (EDCs) are a class of emerging pollutants with considerably high toxicity even at trace levels, so have attained much attention of researchers in recent years. One major pollution source of EDCs is the municipal sewage treatment plants (STP), which are in turn a key node for controlling the discharge of EDCs into our environment. This project, by selecting two typical groups of EDCs (i.e., estrogens and phenols), aims to investigate their distribution pattern, transport and transformation law, degradation mechanisms, and emission risks in several STPs adopting representative biological treatment processes. First of all, based on chromatography-mass spectrometry technologies, highly selective and sensitive analytical methods for comprehensively detecting target EDCs (including free and conjugated forms) in both liquid and solid phases will be developed. Thereafter, the distribution, transport and transformation of target EDCs in three most commonly used treatment process (A/O, A/A/O, Oxidation ditch) will be clarified. The major degradation process and mechanisms will be determined through EDCs mass balance and byproducts identification. The main species and forms of target EDCs present in the effluent and excess sludge will be analyzed. Finally, the potential environmental risk of target EDCs discharged from municipal sewage treatment plants will be assessed by analyzing their estrogenic disrupting activity. The findings of this project are expected to clarify the distribution, transport and transformation, fate and potential risk of EDCs, and thus providing theoretical support to optimize sewage treatment processes.