STRIPAK磷酸酶复合物在果蝇及哺乳动物抗病毒固有免疫中的作用

抗病毒固有免疫系统是生物体对抗病毒感染的第一道防线，其缺陷或调节紊乱会导致严重的病毒感染。高度保守的STRIPAK磷酸酶复合物是调节动物多种生理学过程的一个极其重要的多亚基复合物，其功能紊乱会导致包括肿瘤在内的多种人类疾病。已知STRIPAK磷酸酶复合物在细胞生长、细胞增殖及细胞分化等过程中发挥至关重要的作用，但该复合物在动物抗病毒固有免疫中的作用及分子机制仍不十分清楚。通过果蝇细胞大规模的RNAi筛选，我们发现STRIPAK磷酸酶复合物在果蝇抗病毒免疫中发挥重要作用。本项目将据此进一步解析该复合物参与调控果蝇抗病毒免疫信号通路的分子机理，并探索其在哺乳动物抗病毒免疫中的作用。本项研究将揭示STRIPAK磷酸酶复合物的新生理学功能，并为探究其在哺乳动物抗病毒固有免疫中的作用机理提供基础，为设计抗病毒感染策略提供新的潜在分子靶点。

The antiviral innate immune response is the first line of defense against viral infection, and the dysregulation of it would result in serious viral infection. The highly conserved STRIPAK phosphatase complex plays important roles in cell growth, cell proliferation and cell differentiation. However, whether this complex functions in antiviral immunity remains largely unknown. Through large-scale RNAi screen in Drosophila cells, we found that the STRIPAK phosphatase complex is a critical antiviral immune factor in Drosophila. Based on this finding, the aim of this project is to elucidate the molecular mechanisms of how STRIPAK phosphatase complex regulates antiviral immunity in Drosophila. Moreover, we will further investigate whether this complex is involved in antiviral immunity in mammal. This project will not only enrich our understanding of the novel physiological role of STRIPAK phosphatase complex, but also pave the way for unveiling the underlying mechanism by which this complex regulates mammalian antiviral immunity. This project will provide potential molecular targets for the design of new strategies to combat viral infection.