新型宫腔粘连治疗装置用改性硅橡胶的研制及基础研究

当今妇科领域，宫腔粘连已成为妨碍女性正常生育的重大影响因素。宫腔粘连术后的高复发率是影响治疗效果的瓶颈。在前期工作基础上，本研究拟进一步对新型宫腔粘连装置用硅橡胶进行改性，并揭示添加剂的作用机理，使其满足装置对硅橡胶的物理性能和医学性能要求，从而有效保证治疗效果。本研究正是对该装置用的医用生物材料硅橡胶进一步研究，包括：①优化抗菌剂的添加量，揭示抗菌机理，获取能在子宫特定使用环境下达到最佳抗菌效果的硅橡胶材料；②尝试在硅橡胶中添加抗菌剂的同时，添加有助于子宫内膜再生的雌激素，并探究其释放机理，保证手术后子宫内膜再生速度；③完善硅橡胶的制备技术参数，消除改性物质的添加对硅橡胶材料物理性能的影响，保证宫腔粘连治疗装置对材料的物理性能的要求；④探究此装置用改性硅橡胶的组织相容性和细胞毒性。 该研究将为后期的临床实验奠定基础。

In the gynecologic field, uterine cavity adhesion has become the important factors to interfere with normal birth of female. Postoperative recurrence rate of uterine cavity conglutination highly reduces the treatment effect. The modified silicone rubber, used in the treatment of uterine cavity conglutination new device, effectively guarantees the treatment effect. Study includes the following content. 1) Further optimize the adding amount of antimicrobial and reveals antibacterial mechanism. In order to make the antibacterial silicone rubber, used in the specific environment (womb), has the best antimicrobial property. 2) Try to add estrogen together with antimicrobial at the same time and explore release mechanism. This way can promote the endometrial recovery. 3) Perfect the technological parameter to eliminate the modification of the silicone rubber physical properties. Ensure silicone rubber meet the requirements of the treatment of uterine cavity conglutination new device. 4) Explore organization compatibility and cell toxicity of the modified silicone rubber. The research can be the foundation for the clinical experiment.