B2C电商以较强的渠道掌控能力和终端服务能力，在多种商业模式竞争中优势凸显。但随着零售端顾客服务模式的趋同和服务能力提升空间有限，电商之间的竞争向上游转移。对此，本研究针对电商面临的多品补货和库存协同难题，结合B2C电商多品分类管理实践，以系统成本最小化为目标，在差异化销售策略下研究三个问题：（1）基于电商自主管理库存（RMI）的多品补货与库存协同建模及求解，即对无供应缺货限制自营商品，建立库存容量限制和服务需求响应差异化模型并设计求解算法；（2）基于供应商管理库存（VMI）的多品补货与库存协同建模及求解，即对大品牌供应商品，以多品安全库存约束和服务时间限制建模并设计求解算法；（3）基于供应链整合（SCI）的多品补货和库存建模及求解，即针对战略合同商品，建立供应商与电商库存协同控制模型并设计求解算法。本研究丰富多品补货和库存协同优化理论，研究结果能够为电商补货和库存提供借鉴，具有很强的理论

With strong controlling ability in supply chain channel and service ability in selling end, B2C e-business wins its superior position in the fierce competition with other business modes. However, it has been viewed that the competition among multiple e-businesses is moving from selling the sector to the upper level of the supply chain due to the converged service mode and limited spaces for improving service. Therefore, considering the plight of e-business on coordinating the process of replenishment and inventory management, and the practice of B2C e-business on the classification management of multi-item, with the aim of minimizing the total cost of the whole system, this proposal is unfolded in three aspects: (1) the multi-item replenishment and inventory coordination under retailer inventory management (RMI) mode, that is, to the B2C e-business own managed items, the research model is constructed considering the constraint of storage spaces and service response time, and corresponding solving algorithm is designed; (2) the multi-item replenishment and inventory coordination under vendor inventory management (VMI) mode, that is, to the items supplied by some large brand manufacturers, the research model formulated considering the limitations of safety inventory and the service time disparity, and corresponding solving algorithm is outlined; (3) the multi-item replenishment and inventory coordination under supply chain integration (SCI) mode, that is, to the items supplied according to strategic contract, the supplier and the e-business coordination model is constructed and corresponding solving algorithm is proposed. By enriching the theory of coordination of multi-item replenishment and inventory management, and bringing helpful reference for B2C e-business running, this research shows great significances for theory development and enterprise practical operations.