用于发光功能化聚合物材料合理化设计的单颗粒成像-流式分选方法研究

材料科学领域中，功能化材料的构效关系研究始终占有非常重要的地位，通过深入了解材料理化性质的结构基础，可实现材料的合理化设计。然而，传统的构效关系研究因无法克服粒子间固有不均一性的干扰，只能依赖于目标模糊、效率低下的“条件试错式”实验。因此，我们提出一种基于单颗粒成像和微流控-流式分选的组合方法，用于发光功能化聚合物材料的合理化设计。拟借助高精度的单颗粒成像获取每个粒子的发光性能数据，辅以多种微观结构表征手段，建立构效关系模型，用于指导材料合理化设计。此外，为满足提效、降耗的痛点需求，本项目拟设计一套高通量、自动化的微流控-流式分选系统。该系统通过微流芯片完成材料前处理过程，利用流式分选大幅提升对目标粒子亚群的搜寻效率和富集效率。本项目的顺利实施，不仅可使材料构效关系研究摆脱盲目的“条件试错式”方法，还为单颗粒成像研究领域提供了一种新型、高效的研究模式，对该新兴领域的发展具有积极的推动作用。

Exploring the structure–property relationship of luminescent functional materials plays a central role in materials science, because it holds great promise for the rational design of better materials by understanding the structural basis of the corresponding chemical and physical properties. However, the study of structure-activity relationship have mainly relied on low-efficiency conventional trial-and-error procedures in which the interference of inherent inhomogeneity among particles is indelible under this circumstance. Therefore, we propose a combination method based on single-particle imaging and microfluidic-flow cytometry for the rational design of luminescent functional polymer materials. With the aid of high-precision single-particle imaging and a variety of microstructure characterizations, the structure-activity relationship of the material is established to guide its rational design. In addition, in order to meet the key requirements, this project plans to design and build a high-throughput, automated microfluidic-flow cytometry system. The system performs the material pre-processing through the microfluidic chip, and the flow cytometry system is used to significantly improve the search efficiency and the enrichment efficiency for targeting particle subpopulations. The implementation of this project not only helped the research on structure-activity relationship to get rid of the blind trial-and-error procedures, but also provided a new and efficient research mode for the single-particle imaging, which is playing a positive role in promoting this emerging field.