仿照酶的催化机理，配位超分子笼通过空腔限域作用调节反应，实现催化的专一性和高效性。在之前研究中，含Ru(II)“活性”配位超分子笼可以实现光催化和手性识别，在催化、识别和分子器件方面有潜在应用前景。进一步结合结构调节的策略，有助于实现包合行为的调控，获得普适性仿酶催化应用。本项目拟采用含Ru(II)金属配体为功能构筑片段，以结构转化策略调节“活性”配位超分子笼，从超分子笼的窗口和空腔角度，认识催化中心和限域空间的相互耦合作用，实现超分子笼的包合行为和催化性质在一定范围内连续、精准调控。通过本项目研究，发展配位超分子笼的组装策略，贡献功能导向型的合成方法，提高笼催化机理的认识，加深限域空间尺寸因素的认识，有望发现有应用价值的催化反应。

In imitation of the enzymatic mechanism, the coordination supramolecular cage(metal-organic cage, MOC) could utilize the confined cavity to speed up reactions. In numerous instances, the cavity has been application of achieving highly efficient and specific catalysis. In the last decade, the "active" MOCs based on Ru(II) metalloligand were demonstrated the ability of photocatalysis and chiral recognition, which were essential for the potential applications in catalysis, recognition and molecular devices. Furthermore, the MOCs could allow triggering guest uptake and extending scope of substrates by structure modification strategy. This project intends to realize the functional self-assembling with Ru(II) metalloligand subunits. The utility of structure modification strategy could precisely control the host-guest behavior and cavity catalytic process. Moreover, the coupling system between catalytic center and confined cavity would explain the mechanism of precise catalytic control. Through the research of this project, we would make a positive contribution to functional self-assembling methods and cavity catalytic mechanism. Also, it is expected to determine size effect of confined cavity and find potential application of cavity catalytic transformations.