2型糖尿病（T2DM）患病率逐年增加，给社会带来沉重的疾病和经济负担。研究表明表观遗传学和环境因素指标与干预措施的结局有关，且可用于T2DM的风险预测。本课题组基于前期研究已制定并即将实施慢病综合防控方案，结合查阅的大量文献和前期“环境-基因-T2DM”研究。我们推测ABCG1和TCF7L2基因甲基化可以用于T2DM“三早”的生物学标记物及T2DM进程和风险预测研究。为此，本课题组对防控方案实施下的，不同T2DM阶段的，汉族、维族社区居民各600人，匹配年龄和性别，在方案实施2年前后通过问卷调查以及健康档案采集环境因素数据，采集外周全血检测ABCG1和TCF7L2基因SNP和甲基化水平，借统计学分析方法，探索不同民族T2DM进程诊断的生物学标记物以及用于风险预测和干预评估的可靠的灵敏的指标，并验证风险SNP和DNA甲基化的一致性，为T2DM防控和“3P”医学奠定基础。

The prevalence of type 2 diabetes mellitus (T2DM) is increasing year by year, bringing heavy disease and economic burden to the society. Studies have shown that epigenetics and environmental factors are related to the outcome of interventions and can be used to predict the risk of T2DM.Based on the previous studies, our team has developed and will soon implement the comprehensive prevention and control plan for chronic diseases, combining with a large number of literatures and the previous study on "environment-gene-T2DM".We speculate that the methylation of ABCG1 and TCF7L2 genes can be used to study the biological markers of T2DM, and provide new ideas for the prediction of diabetes progression and risk.Therefore, this research for the prevention and control scheme, under the different stage of T2DM, han and Uighur community residents, 600 people, matched age and sex, through the questionnaire survey and health records data acquisition environment factors, at the same time outside the scheme before and after 2 years to collect comprehensive blood test ABCG1 and TCF7L2 gene SNP and methylation level, through statistical analysis, to explore the different national process of T2DM diagnosis biological markers, and to predict the risk assessment and intervention of reliable and sensitive index, and validate risk SNPS and consistency of DNA methylation,It provides scientific basis for the prevention and control of T2DM and the development of "3P" medicine.