脑血管痉挛(cerebral vasospasm,CVS)是SAH最具特异性的并发症和预后不良的最主要危险因素,其具有以下特点:(1)发生时间窗较为固定,便于具有针对性的选择预防和干预时机;(2)发展多为渐进性,理论上具有足够的干预机会;(3)主要是由于脑血管的功能性异常而非器质性改变引起,理论上具有较高可逆性和治愈期望;(4)与原发病预后关系密切并决定其转归,具有重大的治疗意义。CVS是SAH研究和治疗的最主要靶点。SAH后TRPM4对CVSMCs肌源性紧张度和脑血流自身调节的异常作用与CVS的发生机制有关。本课题计划以在脑血管生理功能中扮演重要角色且较新颖的TRPM4分子作为研究核心,力图阐明其在CVS中的作用和分子机制,为CVS的机制研究和SAH的预后改善提供新兴的科学依据和独特视角。

Cerebral vasospasm is the most specific complications and the important risk factor for poor prognosis of SAH, which has the following characteristics: (1) the occurrence of relatively fixed time window for easy selection of targeted prevention and intervention timing; (2) the development is mostly progressive, theoretically it has enough opportunities for intervention; (3) CVS was mainy due to cerebral vascular functional changes caused by abnormal rather than organic, theoretically it could be reversible and has high expectations of cure; (4) CVShas something with the primary disease and determine its outcome has major therapeutic implications. CVS is the main target for the research and treatment of SAH. After SAH, the effects of TRPM4 for CVSMCs myogenic tone and mechanisms of autoregulation of cerebral blood flow abnormalities were related to CVS. This paper aims to research TRPM4 molecules that play an important role in the cerebrovascular physiological functions and are relatively new as core , trying to clarify its role and molecular mechanisms in CVS in order to provide the scientific basis and a unique perspective for the mechanism of emerging research and the prognosis of CVS in SAH.