针对MBR应用中膜污染控制及抗污染膜材料的制备与优化需求，以抗菌剂季铵盐（QAC）改性PVDF膜为研究对象，围绕基于细菌接触损伤与应激诱导的QAC/PVDF膜抗生物污染机制与调控进行研究，在解析膜面QAC通过直接接触造成细菌损伤机制的基础上，阐释细菌个体损伤所导致的应激诱导相关基因表达及其群体行为调控机制，明晰QAC/PVDF膜生物控制污染的本质，建立以提升抗污染性能为目标、以改善QAC富集效率和优化构筑方式为手段的QAC/PVDF膜制备的调控策略。项目预期能够解释QAC提升PVDF抗污染性能的本质，形成基于抗菌剂控制膜污染的抗污染膜制备技术，为高性能膜材料的开发提供理论与技术支撑，推动MBR技术在污水处理与资源化领域的推广应用。

In order to control membrane fouling and to optimize antifouling membrane materials in membrane bioreactor (MBR) applications, this project tends to study the antibiofouling mechanism and regulation of quaternary ammonium compounds (a kind of antibacterial agent) modified membrane (QAC/PVDF) through the bacterial contact damage and oxidation stress induced community behaviors. On the basis of analyzing the mechanism of bacterial damage caused by QAC direct contact on membrane surface, the nature of biofouling mitigation will be clarified, i.e., the bacterial individual damage leads to oxidation stress which maybe induces relative genes expression for regulation of bacterial community behaviors. The project is designed to establish control measures for improving antifouling property through developing enrichment efficiency of QAC and optimizing its architecture on membrane surface. It is expected to disclose the nature of using QAC to improve PVDF antifouling property, and to develop the technology for preparing antifouling membrane through blending antibacterial agents. The results obtained from this project will provide technical support for developing membrane materials with high-performance, and thus promoting application of MBRs in the field of wastewater treatment and reclamation.