鉴于HER2阳性乳腺癌的高复发转移率和中医药对该病治疗的特色优势，开展中医药防治HER2阳性乳腺癌复发转移的深入研究具有重要意义。本课题在既往临床实践证实乳癌术后方有理想的防治乳腺癌复发转移作用和实验研究显示其抗转移作用主要表现在调节金属蛋白酶（MMPs）这一结果基础上，进一步围绕MMPs和相关肿瘤微环境再进行深入探讨，揭示乳癌术后方在HER2诱导的p38 MAPK信号通路、NF-kB等基因启动因子、肿瘤相关巨噬细胞等在调节MMPs相关肿瘤微环境上的作用，阐释乳癌术后方防治乳腺癌复发转移的机理。

In view of the high recurrence and metastasis rate of HER2-positive breast cancer and the unique features and advantages of the TCM has on it, it is of profound importance to conduct deep-going studies on the TCM for the prevention and treatments of the HER2-positive breast cancer recurrence and metastasis. As the past clinical practice has proved the ideal effects of Ru'ai Shuhou recipe on prevention and treatment of HER2-positive breast cancer recurrence and metastasis, and experimental researches show that the anti-tumor metastasis effect is mainly in regulating MMPs, this study makes further discussion on MMPs and relevant tumor micro-environment, reveals the effects of Ru'ai Shuhou recipe on the HER2-mediated p38 MAPK signaling pathways, gene promoters such as NF-kB, tumor-related macrophage and so on in regulating MMPs-related tumor micro-environment, and interprets the mechanism of the Ru'ai shushou recipe on prevention and treatment of recurrence and metastasis of the breast cancer.