医用钛合金作为主要的骨科植入材料，要求具备优良的生物及力学综合性能。然而在研究优化多元钛合金综合性能时，合金元素对材料显微结构与性能的交叉耦合影响规律，以及材料表面状态的改性优化机制等关键问题仍不明确。针对以上问题，本项目拟研制一种新型Ti-Ta-Nb-Zr-Mo/TiO2-MOx /OCP-Cu-Zn医用钛合金梯度复合材料，借助d电子理论及第一性原理指导合金成分设计，揭示多种元素影响材料性能的物理化学本质；探究多种合金元素对合金显微组织、相变等交叉耦合影响规律，以及合金显微结构对材料生物及力学性能的影响机制；通过物理-化学复合改性在合金表面制备TiO2-MOx/OCP-Cu-Zn涂层，实现微纳米贯通结构活性涂层的构建，对兼具成骨和抗感染多功能复合材料的作用机制和时序表达，及材料与人体组织表介面相互作用机理进行探究，为生物医用钛合金材料的综合性能改善及表面改性提供理论指导。

As a major orthopedic implant material, medical titanium alloys require excellent biological and mechanical properties. However, when researchers attempted to improve multiple comprehensive performance of titanium alloy, some key problems, such as the cross coupling effect of alloy elements on the material microstructure and properties, and modification and optimization mechanism of the material surface, are still not clear. To solve above problems, the present project is to develop a new type of Ti-Ta-Nb-Zr-Mo/TiO2-MOx/OCP-Cu-Zn medical titanium alloy gradient composite material. The alloy composition design will be done under the guidance of d-electronic theory and the primary principle, which will reveal the physical nature that the alloy elements affect material properties. The cross coupling effect of alloy elements on alloy microstructure and phase change, and also the material influence mechanism of the alloy microstructure on biological and mechanical properties will be explored. TiO2-MOx/OCP-Cu-Zn coating will be prepared by physical-chemical modification technology on the alloy surface, which will achieve the building of micro/nano linking structure active coating. Moreover, the action mechanism and temporal expression of osteogenesis and anti-infection multifunctional composite materials, and the interaction mechanism and law of the surface/interface of prepared materials and human tissue, will be investigated. It provides theoretical guidance for the comprehensive performance improvement and surface modification of biomedical titanium alloy materials.