空间偏振高光谱扩散层析成像的中医舌诊定量分析方法研究

舌诊是中医望诊的重要组成部分，实现其定量化对中医临床辨证的准确性至关重要。随着先进光学成像技术的发展，引入光学成像方法并实现多模态成像的相互融合是促进舌诊定量化发展的有效途径之一。本课题首先研究空间偏振高光谱扩散层析成像技术，实现舌体三维非接触空间光检测；其次，通过并行蒙特卡罗算法和辐射传输方程三阶球谐近似，研究基于高光谱扩散层析成像的图像重建方法，获得舌体组织光学特征三维图像，建立舌体组织结构及微循环变化与光学特征变化的联系；再次，探索面向中医舌诊光学特征指数测量方法，基于生物医学光子学理论，通过信息处理与数据挖掘算法，提取若干舌体光学特征指数，解决目前光谱舌诊研究中缺乏统一、客观的定量诊断标准问题；最后，研究该方法在舌体成像及中医舌诊信息提取的定量化能力的应用。该研究所发展的方法不但为中医舌诊定量化提供新的途径，也将为中医临床辨证提供客观依据。

Tongue diagnosis is an important aspect in the inspection of Traditional Chinese Medicine (TCM). Quantitative depiction is crucial in clinical syndrome differentiation of TCM. With the development of advanced optical imaging technology，multimodal optical imaging is an effective approach of objectivity of tongue diagnosis. Firstly, space polarization hyperspectral diffuse technology is investigated to suit non-contact detection of tongue diagnosis; Secondly, to establish relationship between the change of microcirculation changes and optical characteristics. the spectrum tomography image is reconstructed by parallel Monte Carlo algorithm and the radiative transfer equation of third order harmonic approximation; Thirdly, to solve the lack of objective and quantitative diagnostic criteria with spectral methods, surface spectral difference index is extracted by information processing and data mining algorithm which is based on the theory of biomedical photonics; Finally, quantitative ability of the method is studied and the spectral difference index is extracted. The study accurately quantifies by the tongue physiological and pathological information and provides objective basis for clinical efficacy evaluation tongue inspection.