中性条件下钯或镍催化的芳基C-X键对烯烃的加成反应研究

过渡金属催化的sp2 C-X键活化和烯烃的官能团化反应近年来都取得了令人瞩目的成就。本项目创造性的将钯或镍活化的芳基碳-杂键和烯烃官能团化反应有机结合起来，发展高效的、原子经济性的符合绿色化学的新催化体系，旨在以廉价易得的芳基X化物为原料实现芳基C-X键在中性条件下对烯烃的加成反应，同时构建C-X键和C-Ar键。此类反应不仅拓展了芳基sp2 C-X键活化反应，也为烯烃官能团化反应提供了新的思路，实现了在以前氧化条件下不容易得到的新C-X键。该方法学还被应用于一些天然产物或药物分子的全合成中，并将利用各种手段深入研究反应的机理。

Transition metal-catalyzed sp2 C-X bond activation and olefin functionalization reactions have made remarkable achievements in recent years. This project is aimed to develop an efficient, atom economy new catalyst system in line with green chemistry, in which sp2 C-X bond activation and olefin functionalization reactions are creatively combined . The addition reaction between ary C-X and alkenes is realized in neutral conditions with cheap start materials and two new bonds (C-X and C-Ar) are formed. Such reactions not only expand aryl bond sp2 C-X activation reaction, but also provide new ideas for the reaction of the olefin functionalization. Moreover, new interesting bonds are achieved that are not readily available under previous oxidizing conditions. The methodology has also been applied to the total synthesis of natural products or drug molecules, and the mechanism of the reaction also will be further studied with various means.