烯丙位选择性氧化反应是以天然产物为原料制备精细化学品、药物的常用方法。目前环己烯等简单化合物的烯丙位氧化反应已取得了较好的成果，但天然产物具有多个活性位点，现有方法能耗高、选择性差，无法满足绿色生产的要求。本项目在可见光催化氧气氧化的基础上，提出构筑催化活性可调、结构稳定且易回收的吖啶内鎓盐/C3N4有机半导体光催化剂，通过调控催化剂的氧化电势，达到选择性活化烯丙位的目的。不同于传统负载方法，项目设计可用于聚合且氧化电势可调的吖啶内鎓盐光催化剂作为单体，与C3N4前驱体蜜勒胺发生共聚复合，所构建的催化剂具有大π电子共轭结构，可以有效诱导活性中间体的稳定，进一步提高反应的选择性。项目将系统研究催化剂的创制方法及构效关系，建立烯丙位选择性氧化的调控机制，发展巴伦西亚橘烯、胆固醇、齐墩果烷衍生物烯丙位高效分子氧氧化新途径。本项目的顺利完成，将对多活性位点天然产物烯丙位的绿色高效氧化提供技术支持。

Selective allylic oxidation has been widely adopted in the synthesis of fine chemicals and drugs. The oxidation of simple allyls (e.g. cyclohexene) has been successfully achieved. However, the selective oxidation of natural products, which possess multiple active sites, is poor. Based on the visible-light-promoted oxygen oxidation, the proposed project aims at the construction of stable and reusable acridinium/C3N4-based photocatalyst with adjustable catalytic activity. By regulating the oxidation potential of the catalyst, the selective allylic oxidation of compounds with multi active sites shall be achieved. Unlike traditional supported catalysts, acridinium ions with an adjustable oxidation potential will be developed and copolymerized with C3N4 precursor meleramide to obtain catalyst with a long π electron conjugate structure which can enhance the stability of the reactive intermediates, thus further improves the selectivity of the reaction. Subsequently, the structure effect of catalyst, and regulation of the selective allylic oxidation will be conducted. Finally, a protecting-group-free strategy of selective allylic oxidation of (+)-valencene, chloesteryl acetate and oleanane derivatives will be investigated. In future, the green and efficient selective oxidation of allylics shall benefit from this work.